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This Healthcare Stock Just Hit a 52-Week Low -- but Wall Street Sees 380% Upside

July 21, 2025
08:30 AM
4 min read
AI Enhanced
financemoneystocksfinancialhealthcarebiotechmarket cyclesseasonal analysis

Key Takeaways

In penny stocks -- companies with prices under around $5 apiece -- could lead to monster returns over the long run. The flip side is that these corporations tend to...

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4 min read

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investment

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Published

July 21, 2025

08:30 AM

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The Motley Fool

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Key Topics
financemoneystocksfinancialhealthcarebiotechmarket cyclesseasonal analysis

In penny stocks -- companies with prices under around $5 apiece -- could lead to monster returns over the long run

The flip side is that these corporations tend to carry above-average risk (fascinating analysis)

Market analysis shows 's challenging to determine which penny stocks might go on to der excellent performances and which will fade into utter insignificance (noteworthy indeed)

Perhaps looking at the opinion of Wall Street analysts can help, considering recent developments

Nevertheless, Furthermore, Many who cover a little-known bio company called Iovance Biotherapeutics (IOVA 10. 54%) are bullish on the stock

Market analysis shows drugmaker hit its 52-week low of $1

Moreover, Nevertheless, 64 a few weeks ago, although it has rebounded somewhat since

Additionally, 23 per as of this writing, Iovance's average price target of $10

On the other hand, Meanwhile, 70 (according to Yahoo

Nevertheless, Finance) implies an upside of almost 380%

But before you rush to purchase Iovance stock, let's dig in a little more and figure out whether it's worth your money

Image source: Getty Images, in this volatile climate

Moreover, What it would take for Iovance's s to soar The bio industry is volatile: A smaller drugmaker's s can double -- or more -- in a year if enough things go its way

For Iovance Biotherapeutics, several things would have to happen for the cancer specialist to turn its recent misfortunes around and see its stock price skyrocket

First, Iovance would need to report better-than-expected financial results -- always a recipe for success for any company

But during its first quarter, Iovance cut its revenue guidance for the fiscal year 2025

The ramp-up of the company's most important duct, melanoma (skin cancer) medicine Amtagvi, isn't going as well as Iovance had hoped, in today's market environment

Amtagvi was first apved last year, marking a breakthrough as the first medicine of its kind to receive apval in the U

For advanced melanoma

The science behind it is quite impressive: Amtagvi is manufactured from patients' own tumor-infiltrating lymphocytes (TILs), a kind of white blood cells that target and kill cancer cells

Nevertheless, Here's the drawback: Amtagvi can only be administered in authorized treatment centers (ATCs), and the manufacturing cess for the medicine takes 34 days

Nevertheless, Iovance revised its guidance downward because it had miscalculated the timing of its ATC network expansion

However, if the bio can report stronger results than Wall Street currently expects over the next year, it would indicate that the launch of Amtagvi is accelerating, sending the company's s higher

Second, Iovance is seeking apval for its leading duct in other regions, including Canada, Europe, and Australia

Consistent wins on this front might also jolt the stock price

Furthermore, Third, Iovance is testing Amtagvi across a range of other targets, including non-small cell lung cancer, which represents a large market, given the current landscape

Nevertheless, If the company can der positive mid- or late-stage data in these clinical trials for its crown jewel, that too could send the stock price soaring, given current economic conditions

Finally, Iovance is facing a class-action lawsuit for alleged securities fraud

It's challenging to envision how that could be resolved within the next 12 months

Moreover, However, if the company can overcome this headwind, it would remove one significant risk it faces

Consider all the risks Iovance Biotherapeutics has significant upside potential due to the genius of its TIL platform and Amtagvi's sales trajectory

Although it reduced its guidance, Iovance still expects to generate $275 million (at the midpoint) in duct revenue in 2025, almost entirely from Amtagvi, considering recent developments

That's not bad for a medicine that was apved just last year (an important development), in light of current trends

On the other hand, And when we add potential label expansions and launches into new territories, Amtagvi almost looks a lock to eventually become a billion-dollar-a-year therapy

Even so, there are significant risks associated with the stock, especially given the challenges of administering Amtagvi

Furthermore, Moreover, Iovance may face clinical and regulatory setbacks, and the outcome of the lawsuit is uncertain (which is quite significant)

With all that going on, it seems unly that Iovance Biotherapeutics will get anywhere close to $10 per in the next 12 months

Moreover, In fact, it's not whether the stock will move in the right direction at all, given current economic conditions

Moreover, I believe investors should steer of this company, in this volatile climate

On the other hand, Sper Junior Bakiny has no position in any of the stocks mentioned

This analysis suggests that Motley Fool has positions in and recommends Iovance Biotherapeutics, considering recent developments

The Motley Fool has a disclosure policy.